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Drug trial snapshot: Ozempic

What the headline hides: 13.7% weight loss on semaglutide is not a consolation prize

If you try it, a short 812 week test at 12 grams per day is reasonable, but be prepared for little measurable change and prioritize recovery benefits rather than weight loss

Saturation mutagenesis at seven key extracellular domain sites identified positions whose substitution selectively decoupled these two signaling axes, with computational analysis of the resulting sequence-function data revealing correlations between extracellular domain residue chemistry and downstream signaling outcome (Xie et al., 2025)